The Only

Regenerative# Biostimulator

OUR

SKIN EVOLVES

OVER TIME

With age, your skin quietly shifts in the way it looks, feels, and behaves. A softening of facial contours. Lines that linger. What’s really changing is deeper as collagen, elastin, deep soft tissue volume and bony structural support start to fade.9,10 Regenerative# Biostimulator meets your skin where it matters most: at its foundation.

THIS IS

REGENERATIVE
AESTHETICS

AT WORK

Beneath the surface lies your skin’s own ecosystem, known as the extracellular matrix (ECM). Here, vital components work together to keep your skin firm, smooth, and radiant. Over time, this harmony fades.

Our Regenerative# Biostimulator reawakens the dermal fibroblasts within your skin’s ECM through a unique non-inflammatory mechanism of action.

This regenerates the 5 key skin components for healthy and younger-looking skin with lasting results up to 2 years.11-14

WHAT ARE

FIBROBLASTS?

As your skin’s “natural architects”, they are cells in the connective tissues that produce collagen and elastin that give your skin its shape, elasticity, and strength.

5 SKIN

BENEFITS

Support for Collagen I and Long-term Resilience.9
Elasticity for Voluminous Skin.18-20
Glow and Hydration.13,18,20
Nourishment and Long-term Support for Healthy, New Tissues.16
Structure, Elasticity, and Thickness.4,6,15-17

BEYOND

SKIN DEEP

Regenerative Biostimulator supports firmer, stronger, and more radiant skin, with visible results that can last up to 2 years.5,14,19,27-28

0 %
Showed Improved
Smile Lines14
0 %
Showed Improved
Smile Lines14
0 %
Showed Improved
Smile Lines14
0 %
Showed Improved
Smile Lines14

LET'S ZERO IN

Radiesse® revitalises your skin health, contours, and volume so your features reflect not just beauty, but vitality.

Start here: strengthen what’s already yours, in the places that matter most to you.

THESE NUMBERS

SPEAK VOLUMES

From renewed confidence to ongoing trust, Regenerative* Biostimulator continues to make a lasting impression.

0 %
Patient Satisfaction31
0 %
Likely to Continue Regular Treatment32
0 %

Will Recommend32

SKIN-LOVING,

AWARD-WINNING

With a legacy built on results, the Regenerative# Biostimulator has earned trust and accolades across the globe.

Over 20 Years of Scientific and Clinical Experience

Over 15 Million
Syringes Sold
Available Worldwide in
85+ Countries

Trusted by Top Aesthetic Physicians
Around the World21,33

Certified with U.S.
FDA approval
and EU CE mark

New Beauty “Best Filler for Hand Rejuvenation”
2025

Elle “Tools and Treatment Awards”
2024

New Beauty “Favourite Filler for Hand RejuvRejuvenationination”
2024

The Only Regenerative# Biostimulator

#Regenerative refers to the ability to stimulate the production of type I & III collagen, elastin and proteoglycans, as well as increase angiogenesis, cell proliferation and fibroblast contractility.1-8

References:
1. Goldie K. J Cosmet Dermatol. 2023 Mar;22 Suppl 1:1-7.
2. Corduff N. J Cosmet Dermatol. 2023 Mar;22 Suppl 1:8-14.
3. Amiri M, et al. Front Med (Lausanne). 2023 Jun 2;10:1195934.
4. Yutskovskaya Y, et al. J Drugs Dermatol. 2014 Sep;13(9):1047-52.
5. Yutskovskaya Y, et al. J Drugs Dermatol. 2017 Jan 1;16(1):68-74.
6. González N, Goldberg DJ. Dermatol Surg. 2019 Apr;45(4):547-551.
7. Kim J. Clin Cosmet Investig Dermatol. 2019 Oct 15;12:771-784.
8. Courderot-Masuyer C, et al. J Cosmet Dermatol. 2016 Sep;15(3):260-8.
9. Aguilera SB, et al. Aesthet Surg J. 2023;43(10):1063-1090.
10. Mojgan A, et al. Front Med. 2023; 10:1195934.
11. Muti GF, et al. J Drugs Dermatol. 2015:14(9):948-54.
12. van Loghem JV, et al. J Clin Aesthet Dermatol. 2015;8(1):38-49.
13. Durkin A, et al. J Cosmet Dermatol. 2021 Feb;20(2):442-450.
14. Bass LS, Smith S, Busso M, McClaren M. Aesthetic Surgery J. 2010; 30(2):235-238.
15. Zerbinati N. Clin Cosmet Investig Dermatol. 2018;11:29-35.
16. Sundaram H, et al. Dermatol Surg. 2010;36 Suppl 3:1859-65.
17. van Rozelaar L, et. al. Aesthet Surg J. 2014;34(1):118-132.
18. Muti GF. J Drugs Dermatol. 2019;18(1):86-91.
19. Cogorno Wasylkowski V. Clin Cosmet Investig Dermatol. 2015;8:267-73.
20. Schachter D, et al. J Drugs Dermatol. 2016;15(8):1005-10.
21. Data on file.
22. Berlin AL, et al. Dermatol Surg. 2008;34 Suppl 1:S64-7.
23. Marmur ES, et al. J Cosmet Laser Ther. 2004;6(4):223-6.
24. Lemperle G, et al. Aesthet Plast Surg. 2003;27(5):354-366.
25. McCarthy AD, Hartmann C, et al. A morphological analysis of calcium hydroxylapatite and poly-l-lactic acid biostimulator particles. Skin Res Technol 2024;30(6):e13764.
26. Nowag B, et al. Calcium hydroxylapatite microspheres activate fibroblasts through direct contact to stimulate neocollagenesis. Journal of Cosmetic Dermatology 2022;22(2):426-432.
27. Palo JS, de Lima Faria GE, McCarthy AD et al. Improved brachial skin hydration and appearance with hyperdiluted calcium hydroxylapatite. Skin Research and Technology 2024;30:e13835.
28. Moradi A, Green JB, Cohen JL et al. Effectiveness and Safety of Calcium Hydroxylapatite With Lidocaine for Improving Jawline Contour. 2021;20:8.
29. Kim J. Detailed Sonographic Anatomy of Dorsal Hand Augmentation Journal 2019;39(10):1096-1106.
30. Silvers SL, et al. Plast Reconstr Surg. 2006;118(s3):S34–45.
31. Amiri M, et al. A Systematic Review and Meta-analysis of Single-group Studies Assessing the Role of Calcium Hydroxylapatite in Aesthetic Enhancements and Satisfaction. Plastic and Reconstructive Surgery 2024;12:e6400.
32. Moers-Carpi M, et al. Dermatol Surg. 2007;33 Suppl 2:S144-151.
33. Radiesse Instructions for use. Merz North America, Inc.

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