The Only
The Only
Regenerative # Biostimulator
OUR
SKIN EVOLVES
OVER TIME
What’s really changing is deeper as collagen, elastin, deep soft tissue volume and bony structural support start to fade.9,10
Regenerative# Biostimulator meets your skin where it matters most: at its foundation.
THIS IS
REGENERATIVE
AESTHETICS
AT WORK
Beneath the surface lies your skin’s own ecosystem, known as the extracellular matrix (ECM). Here, vital components work together to keep your skin firm, smooth, and radiant. Over time, this harmony fades.
Our Regenerative# Biostimulator reawakens the dermal fibroblasts within your skin’s ECM through a unique non-inflammatory mechanism of action.
This regenerates the 5 key skin components for healthy and younger-looking skin with lasting results up to 2 years.11-14
WHAT ARE
FIBROBLASTS?
As your skin’s “natural architects”, they are cells in the connective tissues that produce collagen and elastin that give your skin its shape, elasticity, and strength.
5 SKIN
BENEFITS
Structure, elasticity, and thickness. ⁴,⁶,¹⁵⁻¹⁷
Support for Collagen I and
long-term resilience⁹
Elasticity for voluminous
skin.¹⁸⁻²⁰
Glow and hydration.¹³,¹⁸,²⁰
Nourishment and long-term
support for healthy, new tissues.¹⁶
BEYOND
SKIN DEEP
Smile Lines14
LET'S ZERO IN
Radiesse® revitalises your skin health, contours, and volume so your features reflect not just beauty, but vitality.
Start here: strengthen what’s already yours, in the places that matter most to you.
LET'S ZERO IN
Radiesse® revitalises your skin health, contours, and volume so your features reflect not just beauty, but vitality.
Start here: strengthen what’s already yours, in the places that matter most to you.
THESE NUMBERS
SPEAK VOLUMES
From renewed confidence to ongoing trust, Regenerative* Biostimulator continues to make a lasting impression.
SKIN-LOVING,
AWARD-WINNING
Over 20 Years of Scientific and Clinical Experience
Over 15 Million
Syringes Sold
Available Worldwide in
85+ Countries
Certified with U.S.
FDA approval
and EU CE mark
New Beauty “Best Filler for Hand Rejuvenation”
2025
Elle “Tools and Treatment Awards”
2024
New Beauty “Favourite Filler for Hand Rejuvenation”
2024
References:
1. Goldie K. J Cosmet Dermatol. 2023 Mar;22 Suppl 1:1-7.
2. Corduff N. J Cosmet Dermatol. 2023 Mar;22 Suppl 1:8-14.
3. Amiri M, et al. Front Med (Lausanne). 2023 Jun 2;10:1195934.
4. Yutskovskaya Y, et al. J Drugs Dermatol. 2014 Sep;13(9):1047-52.
5. Yutskovskaya Y, et al. J Drugs Dermatol. 2017 Jan 1;16(1):68-74.
6. González N, Goldberg DJ. Dermatol Surg. 2019 Apr;45(4):547-551.
7. Kim J. Clin Cosmet Investig Dermatol. 2019 Oct 15;12:771-784.
8. Courderot-Masuyer C, et al. J Cosmet Dermatol. 2016 Sep;15(3):260-8.
9. Aguilera SB, et al. Aesthet Surg J. 2023;43(10):1063-1090.
10. Mojgan A, et al. Front Med. 2023; 10:1195934.
11. Muti GF, et al. J Drugs Dermatol. 2015:14(9):948-54.
12. van Loghem JV, et al. J Clin Aesthet Dermatol. 2015;8(1):38-49.
13. Durkin A, et al. J Cosmet Dermatol. 2021 Feb;20(2):442-450.
14. Bass LS, Smith S, Busso M, McClaren M. Aesthetic Surgery J. 2010; 30(2):235-238.
15. Zerbinati N. Clin Cosmet Investig Dermatol. 2018;11:29-35.
16. Sundaram H, et al. Dermatol Surg. 2010;36 Suppl 3:1859-65.
17. van Rozelaar L, et. al. Aesthet Surg J. 2014;34(1):118-132.
18. Muti GF. J Drugs Dermatol. 2019;18(1):86-91.
19. Cogorno Wasylkowski V. Clin Cosmet Investig Dermatol. 2015;8:267-73.
20. Schachter D, et al. J Drugs Dermatol. 2016;15(8):1005-10.
21. Berlin AL, et al. Dermatol Surg. 2008;34 Suppl 1:S64-7.
22. Marmur ES, et al. J Cosmet Laser Ther. 2004;6(4):223-6.
23. Lemperle G, et al. Aesthet Plast Surg. 2003;27(5):354-366.
24. McCarthy AD, et al. Skin Res Technol. 2024 ;30(6):e13764.
25. Nowag B, et al. J Cosmet Dermatol. 2022;22(2):426-432.
26. Palo JS, et al. Skin Res Technol. 2024;30:e13835.
27. Moradi A, et al. J Drugs Dermatol. 2021; 20(11):1231-1238.
28. Kim J. Aesthet Surg J. 2019;39(10):1096-1106.
29. Silvers SL, et al. Plast Reconstr Surg. 2006;118(s3):S34–45.
30. Amiri M, et al. Plastic and Reconstructive Surgery. 2024;12:e6400.
31. Moers-Carpi M, et al. Dermatol Surg. 2007;33 Suppl 2:S144-151.
32. Radiesse Instructions for use. Merz North America, Inc.
33. Yutskovskaya Y et al., J. Drugs Dermatol. 2020 Apr 1;19(4):405-411.
34. Merz Aesthetics Radiesse Publication Memo, June 2025
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