What is the difference between Radiesse® and Radiesse®+?

Regenerative# Biostimulator

-Formulated wih CaHA microspheres

-For skin quality improvements and wrinkles and folds9-10

-For volumising effects10

Regenerative# Biostimulator+

– Formulated wih CaHA microspheres and an additional 0.3% lidocaine

– For vertical lifting11

– For face and jawline contouring11

How is Regenerative# Biostimulator absorbed by the body?

As a fully biodegradable dermal treatment, Regenerative# Biostimulator will gradually be broken down to calcium and phosphate ions and be absorbed by your body naturally over time.12-15

Has Regenerative# Biostimulator been tested and certified?

Yes, Regenerative# Biostimulator has received both U.S. FDA approval and EU CE mark.

What should I pay attention to after treatment?

Things to do

– Keep treated area cooled to prevent or reduce swelling16

– Avoid applying pressure for 12 to 24 hours

– Avoid extreme warmth or UV light

– Avoid make-up 12 hours after treatment

Things to note

– Avoid treatment if you have a skin infection16

– If you have a history of herpes, you may experience a herpes breakout after treatment16

– Regenerative# Biostimulator microspheres may be visible on X-rays and CT scans

How long do the effects of Regenerative# Biostimulator last?

Depending on the individual’s treatment area, age, skin type, lifestyle and metabolism, Regenerative# Biostimulator effects may last up to 2 years.17

How quickly can I return to work after a Regenerative# Biostimulator treatment?

Due to the safety and tolerability of Regenerative# Biostimulator, you will experience minimal to no downtime after treatment, allowing you to return to work quickly.17

Can Regenerative# Biostimulator be used with other products?

Please consult your aesthetic physician for the possibility of combination treatments within the Merz Aesthetics portfolio, such as incobotulinum toxin A, MFU-V, and Cohesive Polydensified Matrix® hyaluronic acid filler.

How quickly can I return to work after a Regenerative# Biostimulator treatment?

Due to the safety and tolerability of Regenerative# Biostimulator, you will experience minimal to no downtime after treatment, allowing you to return to work quickly.17

How can I learn more about Regenerative# Biostimulator?
Ask your aesthetic physician if Regenerative# Biostimulator is right for you.

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Let us know if you have any queries and
we will get back to you shortly.

#Regenerative refers to the ability to stimulate the production of type I & III collagen, elastin and proteoglycans, as well as increase angiogenesis, cell proliferation and fibroblast contractility.1-8

 References:
1. Goldie K. J Cosmet Dermatol. 2023 Mar;22 Suppl 1:1-7.
2. Corduff N. J Cosmet Dermatol. 2023 Mar;22 Suppl 1:8-14.
3. Amiri M, et al. Front Med (Lausanne). 2023 Jun 2;10:1195934.
4. Yutskovskaya Y, et al. J Drugs Dermatol. 2014 Sep;13(9):1047-52.
5. Yutskovskaya Y, et al. J Drugs Dermatol. 2017 Jan 1;16(1):68-74.
6. González N, Goldberg DJ. Dermatol Surg. 2019 Apr;45(4):547-551.
7. Kim J. Clin Cosmet Investig Dermatol. 2019 Oct 15;12:771-784.
8. Courderot-Masuyer C, et al. J Cosmet Dermatol. 2016 Sep;15(3):260-8.
9. Muti GF, et al. J Drugs Dermatol. 2015:14(9):948-54.
10. Chang JW, et al. J Craniofac Surg. 2020;31(1):e18–21.
11. van Loghem JV, et al. J Clin Aesthet Dermatol. 2015;8(1):38-49.
12. Marmur ES, et al. J Cosmet Laser Ther. 2004;6(4):223-6.
13. Lemperle G, et al. Aesthet Plast Surg. 2003;27(5):354-366.
14. Pavicic T. Clin Cosmet Investig Dermatol. 2015;8:19–25.
15. Chang JW, et al. J Craniofac Surg. 2020;31(1):e18–21.
16. Radiesse Instructions for use. Merz North America, Inc.
17. Bass LS, Smith S, Busso M, McClaren M. Aesthetic Surgery J. 2010; 30(2):235-238.

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