The Only
The Only
SKIN
On The
RESET
It’s universal. The desire to look our best with youthful, healthier skin regardless of age. With our Regenerative# Biostimulator, the Step Zero™ to optimal skin health, we have the power to ‘Reset’ and activate change from within to radiate our best self, now and long after*.
REGENERATIVE
Aesthetics
DEFINED
This is where regenerative aesthetics comes into play. Going beyond superficial improvements, regenerative aesthetics rebuilds the skin ecosystem at its core by improving the functions of the cells, enabling our skin and soft tissue to continuously renew and repair itself to achieve a strong foundation. This will not only achieve a firmer and more youthful look, but also improve your overall skin health that will last now and long after*.6, 10-12
REGENERATIVE#
BIOSTIMULATOR
In Action
Leading the advancement of regenerative aesthetics, our Regenerative# Biostimulator is here to support our skin reset. It is the only regenerative biostimulator that regenerates 5 key components of our skin enabling true repair of aging skin, for healthy and younger-looking appearance.4, 13-15
Look and feel great not just now, but 12 months on or more with lasting results.22
Over 20 years of scientific
and clinical experience
Over 15 million
syringes sold
Available worldwide in
85+ countries
HOW
IT
Works
Formulated with calcium hydroxylapatite (CaHA) microspheres, a naturally occurring mineral found in the body, it creates an aesthetic regenerative scaffold that restores the function of dermal fibroblasts.4, 10, 13-22 The restored dermal fibroblasts allow for collagen I and III synthesis, elastin production, increase in proteoglycans and angiogenesis.
These key components help to rebuild the ECM to deliver noticeable skin quality improvements in the long run.
Our Unique CaHA Particles
Our CaHA microspheres are specially formulated and are one-of-a-kind. What truly sets them apart?
-
Seamless Compatibility
Biocompatible and biodegradable, they are safely broken down and naturally absorbed by the body over time.5, 31-32 -
Optimal Size, Shape and Texture
Being the ideal shape, size, and material, they seamlessly integrate with the skin's natural structure.19, 32-33 They are round, small with a smooth texture free of imperfections that minimises inflammation and elicits a regenerative response.4, 7, 10 -
Highly Uniform
Our CaHA microspheres are consistently of the same size within the range of 25 μm - 45 μm. This uniformity contributes to its regenerative pathway.34
THE PRE-SKINCARE
Aesthetic Treatment
BY MERZ AESTHETICS
Step Zero™ is at the heart of the Skinimalism philosophy and the solution to your yearning for efficiency in skincare to achieve optimal skin quality. Think of it as the foundation of any skincare routine, laying the groundwork for a streamlined route that focuses on the essentials.
Step Zero™ is simple, efficient, and empowering.
Skinimalism
is about being efficient in your skincare routine, where more is less, leading to lasting results.
Foundation for Skincare
Lays the groundwork of an efficient, effective routine.
Improved Skin Quality
Elevates the natural state of the skin, promoting better skin health and appearance.
Natural Results
Aims to enhance the skin’s inherent beauty, not mask it, aligning with the desire for authentic beauty outcomes.
Simplification
Embraces the principle of doing more with less; enabling you to have time for your priorities in life.
RESET
from
WITHIN
Our Regenerative# Biostimulator taps into our inner strength and drives the regeneration of the ECM’s 5 key components for a skin reset. 4, 10, 13-21
Collagen I and III
- Improves skin structure, elasticity, and thickness.4, 6, 23-25
- Both collagen I and III are important types of collagen in the skin. Collagen III stabilises Collagen I fibers when they are produced. As our skin regenerates, Collagen III also matures to Collagen I, providing continued structure and resilience over time.10
Elastin
- An important protein in connective tissues that provides stretchiness. It is 1000x stretchier than collagen.38
- Restores elasticity for voluminous skin.22, 26-27
Proteoglycans
- Proteins that help support skin hydration and glow.15, 22, 27
- Acts as connectors, helping in skin elasticity as well.4-7, 35
- Helps control growth factors that promote skin repair.4-7, 35
Angiogenesis
- Angiogenesis is the formation of new blood vessels that can help transport nutrients that promote skin healing and growth.
- Sustains long-term support for healthy, new tissues by providing nourishment.24
EXPRESS
Your
TRUEST SELF
Unlock your confidence with skin that is not just taut on the surface but genuinely revitalised from within by first choosing your treatment area.29-30
KEEP
Your Skin
IN CHECK
Self-care begins with a skin check-in. Discover the right moment for a reset with this simple self-assessment.
THE
Power
IS YOURS
With a 97% patient satisfaction rate,
know that you are in good hands.37
With a 97% patient satisfaction rate, know that you are in good hands.37
have more
confidence 37
feel more
attractive37
likely to continue
regular treatment37
will recommend37
#Regenerative refers to the ability to stimulate the production of type I & III collagen, elastin and proteoglycans, as well as increase angiogenesis, cell proliferation and fibroblast contractility.1-8
*Long-lasting results of a year or more.12 Individual results may vary.
1. Goldie K. J Cosmet Dermatol. 2023 Mar;22 Suppl 1:1-7.
2. Corduff N. J Cosmet Dermatol. 2023 Mar;22 Suppl 1:8-14.
3. Amiri M, et al. Front Med (Lausanne). 2023 Jun 2;10:1195934.
4. Yutskovskaya Y, et al. J Drugs Dermatol. 2014 Sep;13(9):1047-52.
5. Yutskovskaya Y, et al. J Drugs Dermatol. 2017 Jan 1;16(1):68-74.
6. González N, Goldberg DJ. Dermatol Surg. 2019 Apr;45(4):547-551.
7. Kim J. Clin Cosmet Investig Dermatol. 2019 Oct 15;12:771-784.
8. Courderot-Masuyer C, et al. J Cosmet Dermatol. 2016 Sep;15(3):260-8.
9. Baumann L. J Pathol. 2007;211(2):241-251.
10. Aguilera SB, et al. Aesthet Surg J. 2023;43(10):1063-1090.
11. Casabona G,et al. Plast Reconstr Surg Glob Open. 2017 Jul 25;5(7):e1388.
12. Rovatti PP,et al.Dermatol Surg. 2020 Dec;46(12):e112-e117.
13. Muti GF, et al. J Drugs Dermatol. 2015:14(9):948-54.
14. van Loghem JV, et al. J Clin Aesthet Dermatol. 2015;8(1):38-49.
15. Durkin A, et al. J Cosmet Dermatol. 2021 Feb;20(2):442-450.
16. Radiesse Patient Information Guide (PIG)
17. Radiesse (+) Patient Information Guide (PIG)
18. Radiesse Hands Patient Information Guide (PIG)
19. Draoui O, et al. Calcium Hydroxylapatite Soft Tissue Fillers:
Expert Treatment Techniques. 2021;Ch.1.
20. Amiri M, et al.Front. Med. 2023; 10:1195934.
21. Data on file.
22. Muti GF. J Drugs Dermatol. 2019;18(1):86-91.
23. Zerbinati N. Clin Cosmet Investig Dermatol. 2018;11:29-35.
24. Sundaram H, et al. Dermatol Surg. 2010;36 Suppl 3:1859-65.
25. van Rozelaar L, et. al. Aesthet Surg J. 2014;34(1):118-132.
26. Cogorno Wasylkowski V. Clin Cosmet Investig Dermatol. 2015;8:267-73.
27. Schachter D, et al. J Drugs Dermatol. 2016;15(8):1005-10.
28. Juhász MLW, Marmur ES. Dermatol Surg. 2018;44(8)1084-93.
29. Radiesse (+) Instructions for use. Merz North America, Inc.
30. Radiesse Instructions for use. Merz North America, Inc.
31. Berlin AL, et al. Dermatol Surg. 2008;34 Suppl 1:S64-7.
32. Marmur ES, et al. J Cosmet Laser Ther. 2004;6(4):223-6.
33. Lemperle G, et al. Aesthet Plast Surg. 2003;27(5):354-366.
34. Kunzler C, et al. Poster Presentation IMCAS 2023
35. Goldberga I, et al. Acc Chem Res. 2018;51(7): 1621-1629.
36. Goldie K et al. Clin Cosmet Investig Dermatol. 2021 Jun 14;14:643-654
37. Moers-Carpi, M. et al. Dermatol Surg. 2007;33(Suppl 2):S144–151.
38. J.H. Kristensen, M.A. Karsdal, in Biochemistry of Collagens, Laminins and Elastin, 2016
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